Dr. Prathibha Ranganathan
March 16, 2026 2026-08-13 13:00Dr. Prathibha Ranganathan
Research Areas
- Cancer Therapeutic Resistance
- Tumor Microenvironment
Research
The laboratory focuses on understanding the molecular mechanisms underlying cancer therapeutic resistance and the role of the tumor microenvironment in disease progression.
The research combines molecular and cellular approaches to investigate mechanisms of treatment resistance and identify potential strategies for improving therapeutic response.
Research Projects
Genetic and Epigenetic Landscape of Acquired Chemoresistance
Investigation of the genetic and epigenetic mechanisms associated with acquired chemoresistance and identification of novel therapeutic strategies.
Estrogen Regulation of Tumor Cell-Derived ECM Remodeling Genes
Study of the regulation of tumor cell-derived extracellular matrix remodeling genes by estrogen and the role of key transcription factors.
This project was carried out in collaboration with IIT-G and has been completed.
The Non-Canonical Estrogen Receptor Repertoire in Breast Cancer
Investigation of the non-canonical estrogen receptor repertoire in breast cancer towards refined disease classification and therapeutic decision-making.
This was a multi-centric project involving IIT-Guwahati and B. Barooah Cancer Centre and has been completed.
Molecular Profiling of Tumor Stroma
Molecular profiling of cancer-associated fibroblasts to identify novel strategies for combating therapeutic resistance in cancer.
This research is being carried out in collaboration with the Institute of Nephro-Urology, Bengaluru.
Gene Expression Signatures of Castrate-Resistant Prostate Cancer
Investigation of gene expression signatures associated with castrate-resistant prostate cancer.
This research is being carried out in collaboration with the Institute of Nephro-Urology, Bengaluru.
Molecular Sub-typing of Endometrial Cancer Using microRNA
Investigation of microRNA profiles for molecular sub-typing of endometrial cancer.
This project was carried out in collaboration with Kidwai Memorial Institute of Oncology, Bengaluru and has been completed.
Role of AR and AR Variants in Androgen-Deprivation Resistance
Investigation of the role of androgen receptor (AR) and AR variants, together with associated signalling pathways, in resistance to androgen deprivation.
PhD thesis project.
Drug-Specific Mechanisms of Cancer Chemoresistance
Investigation of drug-specific mechanisms of cancer chemoresistance and identification of potential candidates for combinatorial therapy.
PhD thesis project.
Lab Members
-
Apoorva Abikar
a_apoorva@chg.res.in -
Swathi KA
swathisoraba@chg.res.in
Teaching
- Cancer Biology
- Cell Biology Practicals
Selected Publications
-
ECM (collagen) mediated signaling drives the emergence
of androgen independence in prostate cancer cells.
Apoorva Abikar and Prathibha Ranganathan.
bioRxiv, 2025.07.07.663456.
DOI: 10.1101/2025.07.07.663456 -
Secretome analysis of cancer-associated fibroblasts from
prostate cancer to identify potential therapeutic targets.
Apoorva Abikar et al., Prathibha Ranganathan.
bioRxiv, 2024.12.09.627457.
DOI: 10.1101/2024.12.09.627457 -
Comparative transcriptome of normal and cancer-associated
fibroblasts.
Apoorva Abikar et al., Prathibha Ranganathan.
BMC Cancer, 2024; 24(1):1231.
DOI: 10.1186/s12885-024-13006-x -
microRNA profile of endometrial cancer from Indian patients –
Identification of potential biomarkers for prognosis.
Shraddha Hegde et al., Prathibha Ranganathan.
Biochemical and Biophysical Research Communications,
2024; 39:101812.
DOI: 10.1016/j.bbrep.2024.101812
PMID: 39282095 -
Gene expression signature of castrate resistant prostate cancer.
JM Dixcy Jaba Sheeba et al., Prathibha Ranganathan.
Gene, 2024; 925:148603.
DOI: 10.1016/j.gene.2024.148603
