Dr. Lekha E Manjunath

Research Interests

Mitochondrial biology RNA biology

Research Focus

Cross-talk between mitochondria and protein synthesis.
Mitochondrial retrograde signalling in Complex I disorders.

Selected Publications

Manjunath LE, Singh A, Kumar SD, Vasu K, Kar D, Sellamuthu K, Eswarappa SM. (2024). Transcript-specific induction of stop codon readthrough using a CRISPR-dCas13 system. EMBO Reports, Volume 25, Issue 4, 2118.

DOI: 10.1038/s44319-024-00115-8 ↗

Kar D, Manna D, Manjunath LE, Singh A, Som S, Vasu K, Eswarappa SM. (2023). Kinetics of translating ribosomes determine the efficiency of programmed stop codon readthrough. Journal of Molecular Biology, Volume 435, Issue 21, 168274.

DOI: 10.1016/j.jmb.2023.168274 ↗

Manjunath LE, Singh A, Som S, Eswarappa SM. (2023). Mammalian proteome expansion by stop codon readthrough. WIREs RNA, 14(2), 1739.

DOI: 10.1002/wrna.1739 ↗

Manjunath LE, Singh A, Sahoo S, Mishra A, Padmarajan J, Basavaraju CG, Eswarappa SM. (2020). Stop codon readthrough of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential. Journal of Biological Chemistry, Volume 295, Issue 50, 17009–17026.

DOI: 10.1074/jbc.RA120.014253 ↗

Singh A, Manjunath LE, Kundu P, Sahoo S, Das A, Suma HR, Fox PL, Eswarappa SM. (2019). Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor. EMBO Journal; 38(16): e100727.

DOI: 10.15252/embj.2018100727 ↗